Virus as populations : composition, complexity, dynamics, by Esteban Domingo

By Esteban Domingo

Virus as Populations: Composition, Complexity, Dynamics, and organic Implications explains primary thoughts that come up from concerning viruses as complicated populations whilst replicating in contaminated hosts. basic phenomena in virus habit, similar to model to altering environments, capability to provide sickness, chance to be transmitted or reaction to therapy, rely on virus inhabitants numbers and within the diversifications of such inhabitants numbers. suggestions equivalent to quasispecies dynamics, mutations premiums, viral health, the impact of bottleneck occasions, inhabitants numbers in virus transmission and illness emergence, new antiviral recommendations similar to deadly mutagenesis, and extensions of inhabitants heterogeneity to nonviral structures are integrated. those major thoughts of the e-book are framed in contemporary observations on basic virus variety derived from metagenomic stories, and present perspectives at the starting place of viruses and the function of viruses within the evolution of the biosphere.

  • Features present perspectives at the key steps within the foundation of lifestyles and origins of viruses
  • Includes examples concerning ancestral positive aspects of viruses with their present adaptive capacity
  • Explains advanced phenomena in an equipped and coherent style that's effortless to appreciate and relaxing to read
  • Considers quasispecies as a framework to appreciate virus adaptability and ailment processes

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Extra resources for Virus as populations : composition, complexity, dynamics, and biological implications

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Here again, “heterogeneities” became important: membranes made of mixtures of amphiphiles display increased thermostability, permeability, and tolerance to divalent cations. Budding vesicles endowed with traits such as growth, division, and permeability should have been positively selected for their ability to spread favorable replicating molecules and protocellular functions. 8). According to this model, when cells became independent units surrounded by a lipid membrane, viruses promoted selection of cells that expressed peptidoglycan molecules on their surface to decrease or prevent virus infection.

2000)]. 3). 4). , 2005) and references therein]. 3 Major types of mutations in RNA (U) and DNA (T): four transitions and eight transversions. Below, a means to indicate point mutations, insertion or deletions (known as indels). A genome is depicted as an elongated rod. Symbols on the rod (cross, circle and line) represent mutations. Hypermutation is generally associated with high frequency of specific mutation types (crosses and lines). A region inserted or deleted from the genome is depicted as an empty rod.

161–182. , 2005. Viruses and the Evolution of Life. ASM Press, Washington, DC. , 2008. The Widespread Evolutionary Significance of Viruses. J. ), Origin and Evolution of Viruses, second ed. Elsevier, Oxford, pp. 477–516. , 1988. Before enzymes and templates: theory of surface metabolism. Microbiol. Rev. 52, 452–484. , 1994. Vitalists and virulists: a theory of self-expanding reproduction. In: Bengtson, S. ), Early Life on Earth. Columbia University Press, New York, pp. 124–132. , 2012. Metagenomic characterization of airborne viral DNA diversity in the near-surface atmosphere.

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