The Thymus Gland: Diagnosis and Surgical Management by Kyriakos Anastasiadis, Chandi Ratnatunga

By Kyriakos Anastasiadis, Chandi Ratnatunga

The severe position of the thymus within the immune method is turning into more and more good understood. a lot of this information is greatly dispersed during the literature. even supposing thymectomy is definitely confirmed as a surgery, those advances must be made on hand to the healthcare professional. in addition, neurologists and physicians require a greater realizing of the surgical points of the thymus. This ebook, written by way of chosen specialists, offers an up to date and concise evaluate of the thymus gland for either the doctor and the health professional.

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7. Heidenreich F, Vincent A, Willcox N, Newsom-Davis J. Anti-acetylcholine receptor antibody specificities in serum and in thymic cell culture supernatants from myasthenia gravis patients. Neurology 1988;38:1784–1788. 8. Vincent A, Whiting PJ, Schluep M, Heidenreich F, Lang B, Roberts A, et al. Antibody heterogeneity and specificity in myasthenia gravis. Ann N Y Acad Sci 1987;505:106–120. 9. Storb U. Steps in the generation of autoantibodies. Ann N Y Acad Sci 1993;681:29–32. 10. Schonbeck S, Padberg F, Hohlfeld R, Wekerle H.

As a result, the T cells eventually exported into the peripheral pool recognise self HLA molecules very weakly – except for those occupied by peptides (derived from foreign antigens) that have optimal contact sites for their particular TcRs. Finally, 5–10% of the nascent CD4+ T cells in the medulla develop locally into CD25+ regulatory T cells (T reg) that can dampen or suppress responses of other T cells and prevent them from expanding out of control [4]. “Myasthenia” means weakness of voluntary muscles, and results from defects in neuromuscular transmis- sion.

The apparent autoimmunisation against IFN-α (and IL-12) in thymomas as different as types A and B2 may implicate ubiquitous cell types such as dendritic cells or macrophages. The management of MG has been reviewed by Vincent et al. [59], Palace et al. [60], Richman and Agius [61] and Chapter 6 Thymus and Thymoma in Myasthenia Gravis Patients Newsom-Davis [62]. Though it seldom improves MG, References thymectomy is essential for most patients with thymoma (unless very frail) because of potential invasiveness.

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