The Diabetic Foot: Medical and Surgical Management by Aristidis Veves, John M. Giurini, Frank W. LoGerfo

By Aristidis Veves, John M. Giurini, Frank W. LoGerfo

Within the Diabetic Foot: scientific and Surgical administration, a uncommon panel of clinicians-many working towards on the well-known Joslin-Beth Israel Deaconess Foot Center-illuminate the profitable new multidisciplinary strategy now truly required for the profitable remedy of this clinical challenge. Drawing at the reports of diabetologists, podiatrists, vascular surgeons, infectious ailment experts, orthotists, plastic and orthopedic surgeons, the e-book in actual fact describes verified innovations identified to be powerful. additionally highlighted are the various rising remedies that might impact diabetic foot care within the years forward, together with a brand new figuring out of wound-healing pathophysiology and the hot creation of progress elements and dwelling dermis equivalents.

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Table 2 presents data from two large prospective studies showing that the most common ulcer sites were the toes (dorsal or plantar surface), followed by the plantar metatarsal heads (10,11). The authors caution that ulcer severity is more important than From: The Diabetic Foot: Medical and Surgical Management Edited by: A. Veves, J. M. Giurini, and F. W. , Totowa, NJ 35 36 Reiber Table 1 Population-Based Diabetic Foot Ulcer Incidence and Prevalence from Select Studies Author Population studied Borssen et al.

In one study in diabetic patients undergoing coronary bypass, insulin infusion resulted in better glycemic control and less deep infections than in patients given subcutaneous insulin (91). Insulin infusion may also have beneficial effects on neutrophil function (92). A prospective study is needed to determine whether insulin infusion is beneficial in surgical patients with diabetes who are at high risk for infection and poor wound healing. In summary, the benefits of tight glycemic control in the perioperative period in terms of infection and wound healing are only partly evidence based and must be considered in light of the risks of hypoglycemia and the costs of resource utilization and personnel to deliver the care.

DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992;15:318–368. 19. Rossetti L. Glucose toxicity: the implications of hyperglycemia in the pathophysiology of diabetes mellitus. Clin Invest Med 1995;18:225–260. 20. Buse JB, Polonsky KS. Diabetic ketoacidosis, hyperglycemic hyperosmolar nonketotic coma, and hypoglycemia, in Principles of Critical Care Medicine, 2nd ed. ), McGraw-Hill, New York, 1998, pp. 1183–1193. 21. Arieff AI, Carroll HJ. Nonketotic hyperosmolar coma with hyperglycemia: clinical features, pathohysiology, renal function, acid-base balance, plasma-cerebrospinal fluid equilibria and the effects of therapy in 37 cases.

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