By Daniel Ladant Ph.D, Joseph E. Alouf, Michel R. Popoff D.V.M. Ph.D
Bacterial pollution play an enormous function in infectious ailments. numerous are among the main powerful organic brokers recognized to guy. Cholera, pertussis, botulinum, clostridium and tetanus pollution are all produced by way of micro organism. in lots of situations, it's the toxin produced and never the infectious agent itself that factors pathology. Botulinum toxin has now after all discovered scientific program as botox, and anthrax, and different pollutants, have very likely devastating results if misused as an agent of organic terror. This ebook describes the key achievements and discoveries proper to bacterial protein pollutants because the flip of the recent century, illustrated via the invention of greater than fifty novel pollutants (many of them pointed out via genome screening). The institution of the 3-dimensional crystal constitution of greater than 20 pollution through the related interval bargains deeper wisdom of structure-activity relationships and offers a framework to appreciate how pollution realize receptors, penetrate membranes and have interaction with and regulate intracellular substrates. * Edited by way of of the main very hot specialists within the box from the Institut Pasteur, France * 14 fresh chapters devoted to assurance of ancient and common facets of toxinology * comprises the key pollution of either easy and scientific curiosity are defined intensive * information utilized elements of poisons corresponding to remedy, vaccinology, and toolkits in telephone biology * Evolutionary and practical features of bacterial pollutants evaluated and summarized * Toxin functions in cellphone biology provided * treatment (cancer treatment, dystonias) mentioned * Vaccines (native and genetically engineered vaccines) featured * pollutants mentioned as organic guns, comprising chapters on anthrax, diphtheria, ricin and so on.
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Extra info for The Comprehensive Sourcebook of Bacterial Protein Toxins
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