Textbook of Nephro-Endocrinology, 1st Edition by Ajay K. Singh MB FRCP, Gordon H. Williams

By Ajay K. Singh MB FRCP, Gordon H. Williams

The Textbook of Nephro-Endocrinology is the definitive translational reference within the box of nephro-endocrinology, investigating either the endocrine services of the kidneys and the way the kidney acts as a goal for hormones from different organ platforms. It bargains either researchers and clinicians professional, gold-standard research of nephro-endocrine learn and translation into the remedy of ailments resembling anemia, power kidney illness (CKD), rickets, osteoprosis, and, hypoparathyroidism. * Investigates either the endocrine services of the kidneys and the way the kidney acts as a goal for hormones from different organ platforms. * offers a uniquely accomplished and cross-disciplinary examine all points of nephro-endocrine issues in a single reference paintings. * transparent translational shows via the pinnacle endocrinologists and nephrologists in each one particular hormone or functional/systems box.

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Microcytic (MCV < 80 fl) * Iron-deficiency anemia * Thalassemia * Anemia of chronic disease * Sideroblastic anemia (hereditary, lead) b. Normocytic (MCV 80–100 fl) * Nutritional anemias, including iron-deficiency * Anemia of renal insufficiency * Hemolytic anemias Red cell intrinsic etiologies including membranopathies, enzymopathies, hemoglobinopathies; Red cell extrinsic causes including drug, virus and lymphoid associated anemias and transfusion reactions Microangiopathic anemias (TTP/HUS) Infection associated * Anemia of chronic disease * Bone marrow disorders Aplastic anemia Pure red cell aplasia Ineffective erythropoiesis c.

2006). Indeed, altering the molecular weight of the starch moiety has been shown to alter the pharmacological properties of the compound. B. , 1999). One such compound was found, but this bound to only a single chain of the erythropoietin receptor and was not biologically active. The compound was ligated to enable it to interact with both domains of the EPO receptor and this second molecule was shown to stimulate erythropoiesis. Further development of non-peptide EPO mimetics could lead to the production of an orally-active ESA in the future.

Secondly, patients with antibody-mediated pure red cell aplasia should be able to respond to Hematide therapy by an increase in their hemoglobin concentration, since Hematide is not neutralized by anti-erythropoietin antibodies. , 2007b). Thus, rats receiving regular injections of recombinant human erythropoietin were shown to develop anti-EPO antibodies. , 2007b). , 2007b). Other peptide-based ESAs are in pre-clinical development. , 2006). Indeed, altering the molecular weight of the starch moiety has been shown to alter the pharmacological properties of the compound.

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