By Russell, Hugo and Ayliffe
Hugely revered, verified textual content – a definitive reference in its box – overlaying intimately many tools of the removing or prevention of microbial growth"highly instructed to health center and study group of workers, particularly to scientific microbiologists, infectioncontrol and environmental-safety experts, pharmacists, and dieticians."New England magazine of MedicineWHY purchase THIS BOOK?Completely revised and up-to-date to mirror the fast velocity of switch during this quarter up to date fabric on new and rising applied sciences, targeting distinctive difficulties in hospitals, dentistry and pharmaceutical perform offers sensible propose on difficulties of disinfection and antiseptics in hospitalsDiscusses expanding difficulties of typical and purchased resistance to antibioticsNew individuals provide a clean method of the topic and confirm overseas coverageSystematic overview of sterilization tools, with makes use of and benefits defined for eachEvaluation of disinfectants and their mechanisms of motion
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Additional info for Russell, Hugo and Ayliffe's Principles and Practice of Disinfection, Preservation and Sterilization
1996). 7 Salicylic acid This is often used, in combination with benzoic acid and other antifungal agents, for the topical treatment of fungal infections. Salicylic acid has keratinolytic activity and in addition affects metabolic processes. For an account of the action of benzoic and salicylic acids on the metabolism of microorganisms, see Bosund (1962) and Freese et al. (1973). 1% in water; the sodium salt is soluble to the extent of 33%. 3; B. 1; Staph. 3; P. 4; A. 05; T. 1. Extensive toxicological studies have indicated that the product is acceptable as a preservative for foods, cosmetics and medicines.
6 Organic acids and esters. cially in the food industry. Some, for example benzoic acid, are also used in the preservation of pharmaceutical products; others (salicylic, undecylenic and again benzoic) have been used, suitably formulated, for the topical treatment of fungal infections of the skin. Vinegar, containing acetic acid (ethanoic acid) has been found to act as a preservative. It was also used as a wound dressing. This application has been revived in the use of dilute solutions of acetic acid as a wound dressing where pseudomonal infections have occurred.
Typical MICs (bacteriostatic) in mg/mL are: Staph. 9; B. 2; Proteus vulgaris, 4; E. coli, 28; P. aeruginosa, 25. It has found chief application as an active ingredient in surgical scrubs and medicated soaps and has also been used to a limited ex21 Chapter 2 tent as a preservative for cosmetics. Its use is limited by its insolubility in water, its somewhat narrow antibacterial spectrum and by the fact that in the UK it is restricted by a control order made in 1973. 75% in animal medicines. 1%, with the stipulation that it is not to be used in products for children or personal hygiene products.