Principles of Molecular Virology by Alan J. Cann

By Alan J. Cann

The 5th version of the hugely profitable Principles of Molecular Virology takes on a molecular method of the reason of virology, featuring easy in a transparent, concise and student-friendly demeanour. This totally up to date undergraduate textual content explores and explains the basic elements of virology, together with constitution of virus debris and genome, replication, gene expression, an infection, pathogenesis and subviral brokers. an internet site with self-assessment questions and different assets aids in pupil realizing.

  • Completely rewritten and updated
  • Clear and simple to understand
  • Examples masking very important principles in virology
  • All new illustrations
  • Accompanying web site with interactive assets and educating fabric for instructors

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Example text

N Transmembrane proteins contain multiple hydrophobic domains that may form a protein-lined channel through the envelope. , ion channels). , the influenza virus M2 protein). Although there are many enveloped vertebrate viruses, only a few plant viruses have lipid envelopes. Most of these belong to the Rhabdoviridae family, whose structure has already been discussed (see “Helical Symmetry”). Except for plant rhabdoviruses, only a few bunyaviruses that infect plants and members of the Tospovirus genus have outer lipid envelopes.

Of myristic acid, a 14-carbon unsaturated fatty acid). Five VP4 monomers form a hydrophobic micelle, driving the assembly of a pentameric subassembly. 10 Proteolytic processing of picornavirus capsid proteins. Picornavirus proteins (and those of other single-stranded positive-sense RNA viruses) are produced by cleavage of a long polyprotein into the final products needed for replication and capsid formation (see Chapter 5). The Function and Formation of Virus Particles chemistry, structure, and symmetry of the proteins that make up the picornavirus capsid reveal how the assembly is driven.

7 (4), e1000092. CHAPTER 3 Genomes WHAT’S IN THIS CHAPTER? n n n We start by describing the diversity of virus genomes. To understand how this affects virus replication, we consider the major genetic mechanisms that affect viruses. We finish by looking at representative virus genomes to illustrate the various possibilities. THE STRUCTURE AND COMPLEXITY OF VIRUS GENOMES Unlike the genomes of all cells, which are composed of DNA, virus genomes may contain their genetic information encoded in either DNA or RNA.

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