By Nanette F. Santoro, Amber R. Cooper
Presenting the most up-tp-date and proper details at the analysis and administration of fundamental ovarian insufficiency, sometimes called untimely ovarian failure (POI/POF), this ebook provides both very important voices. the 1st is the clinical, evidence-based voice discussing the most recent info on POI/POF in a concise and logical model: etiologies, signs, genetics, mechanisms, linked stipulations, in addition to mental and way of life issues. the second one voice provides the first-person tales of affected girls, who're usually confronted with a analysis of irreversible infertility at a really younger age and who in some way learn how to dwell with nice uncertainty approximately their skill to create a family members – a center identification factor for plenty of ladies. it really is therefore no longer easily a medical, case-based presentation, yet a extra collaborative attempt among clinicians who're well-versed within the box and girls who've POI/POF. Primary Ovarian Insufficiency: A scientific consultant to Early Menopause will accordingly be an outstanding functional but own reference for OB/GYNs, reproductive medication experts, and any clinician, nurse or well-being care employee treating girls dwelling with POI/POF.
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Extra info for Primary Ovarian Insufficiency: A Clinical Guide to Early Menopause
In a randomized controlled trial of women undergoing either hysterectomy or UAE, both groups were found to have a significant increase in FSH compared to baseline and a significant reduction in AMH levels compared to the age expected levels at the end of the 24-month followup . The effect of UAE on ovarian reserve has been found to be equal to that of hysterectomy and myomectomy [186–189]. POI can occur following surgery for bilateral endometriomas [190–192]. 4 %, but further confirmation is warranted.
Borman SM, et al. Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index. Toxicol Appl Pharmacol. 2000;167(3):191–8. 138. Pru JK, et al. Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons. Reprod Sci. 2009;16(4):347–56. 139. Springer LN, et al. Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats.
When symptoms persist over time, the right combination of treatments to manage symptoms is attainable for many. 4 at the final menses . Age-appropriate menopause is often accompanied by hot flashes, night sweats, sleep problems, mood changes, and vaginal dryness . POF/ POI is also associated with these symptoms. POF/POI occurs earlier in life and is more likely to be marked by a return of menses, ovulation, and possibly pregnancy [17–21]. In contrast with age-appropriate menopause, women with POF/POI have frequent evidence of sporadic ovarian function and pregnancy, sometimes long after the diagnosis is established .