By K.M.J. Menon PhD, Aaron Goldstrohm PhD
This booklet examines how post-transcriptional mechanisms regulate endocrine functionality. This comprises newly pointed out regulatory mechanisms eager about hormone biosynthesis, keep an eye on of hormone receptors and the outputs of hormone mediated sign transduction. Chapters handle endocrine hormones together with protein peptide/peptide, steroid, and non-steroidal hormones. The affects of those mechanisms on disorder and healthiness are lined, supplying a unique replace to the medical literature.
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Additional resources for Post-transcriptional Mechanisms in Endocrine Regulation
Arvola et al. Endonucleolytic mRNA decay is also an important for stress response. The IRE1 protein is a transmembrane endoribonuclease located on the endoplasmic reticulum. During stress conditions, IRE1 decays mRNAs through the regulated IRE1 dependent decay (RIDD) pathway (Hollien et al. 2009; Maurel et al. 2014) (Fig. 4). IRE1 substrates are speciﬁcally associated with the ER and decay faster during stress conditions to reduce translation (Gaddam et al. 2013 ). Additionally, these substrate mRNAs are highly enriched for transcripts involved in secretory pathways, including the hormone insulin and multiple cell surface receptors (Han et al.
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