Post-transcriptional Mechanisms in Endocrine Regulation by K.M.J. Menon PhD, Aaron Goldstrohm PhD

By K.M.J. Menon PhD, Aaron Goldstrohm PhD

This booklet examines how post-transcriptional mechanisms regulate endocrine functionality. This comprises newly pointed out regulatory mechanisms eager about hormone biosynthesis, keep an eye on of hormone receptors and the outputs of hormone mediated sign transduction. Chapters handle endocrine hormones together with protein peptide/peptide, steroid, and non-steroidal hormones. The affects of those mechanisms on disorder and healthiness are lined, supplying a unique replace to the medical literature.

Post-transcriptional regulatory mechanisms play a necessary function in controlling dynamic gene expression. the end result of this legislation contains keep watch over of the quantity, timing, and site of protein expression. legislation is mediated by means of cis-acting RNA sequences and constructions and transacting RNA binding proteins and non-coding RNAs, together with microRNAs. fresh advances in characterization of those regulatory elements have published huge, immense regulatory strength.

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Arvola et al. Endonucleolytic mRNA decay is also an important for stress response. The IRE1 protein is a transmembrane endoribonuclease located on the endoplasmic reticulum. During stress conditions, IRE1 decays mRNAs through the regulated IRE1 dependent decay (RIDD) pathway (Hollien et al. 2009; Maurel et al. 2014) (Fig. 4). IRE1 substrates are specifically associated with the ER and decay faster during stress conditions to reduce translation (Gaddam et al. 2013 ). Additionally, these substrate mRNAs are highly enriched for transcripts involved in secretory pathways, including the hormone insulin and multiple cell surface receptors (Han et al.

Cold Spring Harb Perspect Biol 4:a013706 Diederichs S (2014) The four dimensions of noncoding RNA conservation. Trends Genet 30:121–123 Ebert MS, Sharp PA (2010) Emerging roles for natural microRNA sponges. Curr Biol 20:R858–R861 Elkon R, Ugalde AP, Agami R (2013) Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet 14:496–506 Esau C, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R et al (2004) MicroRNA-143 regulates adipocyte differentiation.

Genetics 5:316–323 Maurel M, Chevet E, Tavernier J, Gerlo S (2014) Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem Sci 39:245–254 Meister G (2013) Argonaute proteins: functional insights and emerging roles. Nat Rev Genet 14:447–459 Meyuhas O, Kahan T (2015) The race to decipher the top secrets of TOP mRNAs. Biochim Biophys Acta 1849:801–811 Michel YM, Poncet D, Piron M, Kean KM, Borman AM (2000) Cap-Poly(A) synergy in mammalian cell-free extracts. Investigation of the requirements for poly(A)-mediated stimulation of translation initiation.

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