Osteoimmunology: Interactions of the Immune and Skeletal by Joseph Lorenzo, Mark Horowitz, Yongwon Choi, Hiroshi

By Joseph Lorenzo, Mark Horowitz, Yongwon Choi, Hiroshi Takayanagi

Bone and the immune approach are either complicated tissues, which, respectively, keep an eye on the skeleton and the body's responses to invading pathogens. severe interactions among those organ structures usually occur, particularly in the advance of immune cells within the bone marrow and for the functionality of bone cells in healthiness and disorder. This e-book offers an in depth evaluation of the numerous ways in which bone and immune cells have interaction. The objective is to supply simple and medical scientists with a greater knowing of the function that the immune procedure and bone play within the improvement and serve as of one another in order that advances in either fields may be facilitated.
The concentration of the publication may be either on simple pathways and translational technology, to be able to follow simple wisdom to scientific illnesses. bankruptcy content material will variety from simple descriptions of some of the cellphone platforms and their improvement to the signs that lead them to have interaction in the course of general body structure and disorder. this can be a swiftly constructing sector that's of curiosity to a large spectrum of researchers, scholars, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom have to improve a extra entire realizing in their formerly separate disciplines and the mechanisms wherein they interact.

  • Presents a complete, translational resource for all elements of osteoimmunology in a single reference work

  • Experts in bone biology and immunology (from all components of educational and scientific learn) take readers from the bench examine (cellular and molecular mechanism), via genomic and proteomic research, all of the method to medical research (histopathology and imaging) and new healing approaches.

  • Clear displays via bone biologists of the mobile and molecular mechanisms underlying bone telephone improvement resulting in bone and immunological ailments akin to Lupus

  • Clear shows through immunologists of the way immune cells boost and the way the immune process performs a task in bone ailments like osteoporosis and arthritis

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Extra info for Osteoimmunology: Interactions of the Immune and Skeletal Systems

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M-CSF and sRANKL induce osteoclastogenesis, while GM-CSF with sRANKL (or GM-CSF plus IL-4) induces dendritic cell differentiation from single common precursors (c-KitþCsf1RþRANKÀ cells) that can also form macrophages [30]. M-CSF and GM-CSF appear to antagonize each other in the regulation of osteoclast vs. dendritic cell differentiation. However, the effect of GM-CSF on osteoclastogenesis is biphasic as it supports the generation of CFU-GM, which are efficient osteoclast precursors, but later inhibits human osteoclastogenesis while promoting the formation of CD1aþ/TRAPÀ DC clusters [31].

The cytoplasmic domain of RANK is unique in that there are at least three independent TIM regions. Although several TRAF family members are recruited to bind RANK, TRAF6 binds to a unique set of TIM sites and is critical for RANK signaling. TRAF2, TRAF3, and TRAF5 bind to two regions near the C-terminus, whereas TRAF6 binds to a highly specific membrane-proximal TIM. Deficiency of either TRAF2 [55] or TRAF5 [56] in osteoclast progenitors had only a minor effect on RANKL-induced osteoclastogenesis, although the TRAF2 deficiency had a large effect on the ability of TNFa to support osteoclastogenesis.

Regulation of osteoclast differentiation. Ann N Y Acad Sci 2006 Apr;1068:100–9. [18] Tinkler SM, Linder JE, Williams DM, Johnson NW. Formation of osteoclasts from blood monocytes during 1 alpha-OH Vit D-stimulated bone resorption in mice. J Anat 1981 Oct;133(Pt 3):389–96. [19] Zambonin Zallone A, Teti A, Primavera MV. Monocytes from circulating blood fuse in vitro with purified osteoclasts in primary culture. J Cell Sci 1984 Mar;66:335–42. [20] Tsurukai T, Takahashi N, Jimi E, Nakamura I, Udagawa N, Nogimori K, et al.

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