Myeloproliferative Neoplasms: Critical Concepts and by Robert Kralovics (auth.), Tiziano Barbui, Ayalew Tefferi

By Robert Kralovics (auth.), Tiziano Barbui, Ayalew Tefferi (eds.)

This publication makes a speciality of 3 of the most different types of myeloproliferative neoplasm: polycythemia vera, crucial thrombocythemia, and first myelofibrosis. correct laboratory and scientific advances are comprehensively lined, and nice emphasis is put on the sensible matters that problem physicians of their day-by-day perform. the most issues thought of therefore contain modern diagnostic methods, the worth and barriers of mutation screening for diagnostic and prognostic reasons, possibility stratification when it comes to either survival and different sickness issues reminiscent of leukemic transformation and thrombosis, and sleek healing techniques, together with traditional medications, allogeneic stem telephone transplantation, and experimental medicinal drugs nonetheless less than examine. The reader will locate Critical options and administration ideas in Myeloproliferative Neoplasms to be a useful and updated resource of data from prime specialists within the field.

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2005; James et al. 2005; Kralovics et al. 2005; Levine et al. 2005). This is a gain-of-function acquired mutation in a bone marrow clone which leads to a constitutively active JAK2 protein. In a further group of patients with erythrocytosis, different mutations in exon 12 of the JAK2 gene were discovered (Scott et al. 2007; Percy et al. 2007). These mutations can be detected in the peripheral blood with increasingly sensitive techniques, and it is possible to detect the presence of small clones (Chen et al.

J Clin Pathol 64:226–231 Boveri E, Passamonti F, Rumi E et al (2008) Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations. Br J Haematol 140:162–168 Brousseau M, Parot-Schinkel E, Moles MP et al (2010) Practical application and clinical impact of the WHO histopathological criteria on bone marrow biopsy for the diagnosis of essential thrombocythemia versus prefibrotic primary myelofibrosis. Histopathology 56:758–767 Buhr T, Georgii A, Schuppan O et al (1992) Histologic findings in bone marrow biopsies of patients with thrombocythemic cell counts.

There are also patients with congenital erythrocytosis/polycythaemia with mutations in the von Hippel–Lindau gene who have had their bone marrow interpreted as consistent with PV (Gordeuk et al. 2005), so the discriminatory power of the described bone marrow changes may not be sufficient. Widespread prospective use may be difficult, requiring very specific expertise, and this haematopathology experience may not be widely available. It may also be difficult to persuade patients and justify the expense of the widespread use of bone marrow biopsy to add to the diagnostic pathways in those who fulfil other criteria using less invasive tests.

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