Muscle Metabolism by Zierath, Juleen R

By Zierath, Juleen R

Diabetes examine on versions comprising intact animal tissues, cellphone cultures and remoted pancreatic islets is vital for figuring out the pathogenesis of the illness in addition to the mechanisms answerable for the power problems linked to it. huge, immense advances within the realizing of the advance of diabetes and its prevention have lately been derived from paintings with such animal versions. This e-book offers the state of the art wisdom within the box of diabetes examine directed at figuring out the mechanisms governing the improvement of skeletal muscle insulin resistance. Muscle Metabolism can be of vital curiosity for these getting to know diabetes at an experimental point in either academia and the pharmaceutical undefined. additionally, it's going to even be of curiosity to researchers within the fields of weight problems, metabolism, endocrinology and molecular biology

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Thus, these data and data from genetically altered mice suggest that while impaired glucose uptake is a critical factor in the development of type 2 diabetes, the insulin-stimulated component of glucose uptake in muscle may not be as important as the contraction/exercise-stimulated component of glucose uptake. This analysis is consistent with the dramatic improvement in glucose tolerance observed with exercise in animals and humans with type 2 diabetes. These observations fit well with the notion that the liver (not muscle) controls minute-to-minute glucose levels and that muscle contraction is responsible for a large component of glucose disposal into muscle.

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1995). Thus, these data and data from genetically altered mice suggest that while impaired glucose uptake is a critical factor in the development of type 2 diabetes, the insulin-stimulated component of glucose uptake in muscle may not be as important as the contraction/exercise-stimulated component of glucose uptake. This analysis is consistent with the dramatic improvement in glucose tolerance observed with exercise in animals and humans with type 2 diabetes. These observations fit well with the notion that the liver (not muscle) controls minute-to-minute glucose levels and that muscle contraction is responsible for a large component of glucose disposal into muscle.

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