Molecular Basis of Reproductive Endocrinology by C. T. Bond, R. Fernald, R. Francis, N. Sherwood, J. P.

By C. T. Bond, R. Fernald, R. Francis, N. Sherwood, J. P. Adelman (auth.), Peter C. K. Leung Ph.D., Aaron J. W. Hsueh Ph.D., Henry G. Friesen M.D. (eds.)

Recent advances in molecular biology have supplied new dimensions within the examine of the reproductive process. there was significant development in our figuring out of the molecular mechanisms of hormone motion some time past few' years. The symposium on "Molecular foundation of Reproductive Endocrinology" was once geared up to focus on new learn findings at the rules of the hypothalamic-pituitary-gonadal axis. The emphasis of the symposium was once on physiological questions responded by means of the molecular biology technique. reviews at the practical relevance of gonadotropin liberating hormone and LH and FSH gene expression have been provided, including examine at the molecular biology of ovarian and testicular steroidogenic enzymes and protein hormones. additionally, a number of novel points of hormone gene expression in placental tissues have been reviewed. The symposium was once held July 25 to 26, 1991, instantly ahead of the twenty fourth Annual assembly of the Society for the research of copy, at the campus of the collage of British Columbia in Vancouver. Serono Symposia, united states generously financed and coordinated the assembly. we're indebted to Dr. Bruce okay. Burnett and Dr. L. Lisa Kern for his or her expert advice within the association of the symposium. we might additionally wish to thank Drs. Victor Gomel, Basil Ho Yuen, and John Challis, who served as consultation moderators. such a lot of all, we actually relish the efforts of all of the invited audio system, poster presenters, and discussants in making this a memorable occasion because the biggest one-day assembly of the Serono Symposia united states, series.

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Biochem Biophys Res Commun 1972;49:863-9. 22. Fujino M, Fukuda T, Shinagawa S, Kobayashi S, Yamazaki I, Nakayama R. Synthetic analogs of luteinizing hormone releasing hormone (LH-RH) substituted in position 6 and 10. Biochem Biophys Res Commun 1974; 60:406-13. 23. Conn PM, Rogers DC, Seay S, et al. Receptor-effector coupling in the pituitary gonadotrope. In: McKerns KW, Naor Z, eds. Biochemical endocrinology. New York: Plenum Press, 1984:153-73. 24. Hook W A, Karten M, Siraganian RP. Histamine release by structural analogs of LHRH [Abstract 5336].

M. Conn already present on gonadotropes and requires the simultaneous administration of the phorbol ester and GnRH agonist (178). As the effect of phorbol ester to unmask GnRH receptors occurs within 20 min of treatment, the observed effects of phorbol esters are likely not similar to the up-regulation induced by GnRH. Moreover, these "phorbol ester unmasked" GnRH receptors appear to be selectively uncoupled to phosphoinositide metabolism (63) and have a similar rate of synthesis to GnRH receptors normally present on gonadotropes (96).

Regulation of the synthetic rate of gonadotropin-releasing hormone receptors in rat pituitary cell cultures by inhibin. Endocrinology 1990;127:2387-92. 88. Conn PM, Rogers DC, Stewart 1M, Niedal J, Sheffield T. Conversion of a gonadotropin-releasing hormone antagonist to an agonist. Nature 1982; 296:653-5. 89. Conn PM. Ligand dimerization: a technique for assessing receptor-receptor interactions. Methods Enzymol 1983;103:49-58. 90. Pelletier G, Dube D, Guy J, Sequin C, Lefebvre FA. Binding and internalization of a luteinizing hormone-releasing hormone agonist by rat gonadotrophic cells, a radiographic study.

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