Molecular and Cellular Endocrinology of the Testis by A. Chauchereau, A. Mantel, K. Delabre (auth.), G. Verhoeven,

By A. Chauchereau, A. Mantel, K. Delabre (auth.), G. Verhoeven, U.-F. Habenicht (eds.)

The ecu Workshops on Molecular and mobile Endocrinology of the Testis became by way of now a well-established culture. because of their specified structure, the standard of the most lectures and miniposters, and the shiny discussions, they benefit from the ever-increasing curiosity and energetic participation of all ecu scientists operating within the box. additionally, because the very starting they've got attracted investigators from around the world. the newest "Testis Workshop" used to be held in De Panne, Belgium, from 27-3\ March, 1994. As regularly, the body­ paintings of the workshop was once supplied via a sequence of lectures introduced via a panel of the world over famous experts. those lectures are ga­ thered within the current quantity of the Ernst Schering beginning paintings­ store sequence. including the Miniposter e-book they represent an excel­ lent written account of the complaints of the eighth eu Testis Workshop. The testis certainly represents probably the most advanced and in­ triguing tissues within the physique. either its endocrine functionality, the secretion of male intercourse hormones, and its exocrine position, the construction of mature spermatozoa, proceed to elevate startling inquiries to clinicians, physi­ ologists, endocrinologists, and scientists interested by primary re­ seek. Few organs preserve and help a differentiation method as advanced as spermatogenesis; few tissues constantly demonstrate either mitotic and meiotic cellphone cyles in one of these stringently managed style or a similar want for coordinated endocrine and native control.

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These grafts only produced mild androgenization and incomplete restoration of androgen-dependent target organs; furthermore, the sexual behaviour of the castrated hosts failed to return to normal (Fox et al. 1973; Boyle et al. 1976; Tai et al. 1989; van Dam et al. 1989). Since the grafts grew well (Fig. 4), the problem may lie in the abnormal tissue architecture and/or the absence of paracrine signals from cells in the seminiferous tubules, which may be necessary for nonnal cellular differentiation (Tahka 1986).

In adult hypophysectomized, EDS-treated rats, proliferation of Leydig cell precursors and the first part of the differentiation process of these cells along the Leydig cell lineage can take place in the absence of LH and other pituitary hormones (Teerds et al. 1989b). To date it is not known which (growth) factors allow these processes to proceed and whether these factors are locally produced by, for instance, Sertoli cells or testicular macrophages. Further development of the partially differentiated precursor cells in hypophysectomized, EDS-treated rats into Leydig cells occurred only after hCG administration (Teerds et al.

Despite the presence of a developing tubule system, the postnatal testis still has some cellular plasticity, -which is encouraging. For example, when the immature testis is completely disaggregated into a single cell preparation and then reag~d and transplanted to an adult host, the Sertoli cells reorganize to-form tubules of normal diameter. Most of the tubules are sterile, as expected, but some spermatogonial stem cells are found within them and undergo meiotic transformati- Transplantation of Male and Female Germ and Somatic Cells 27 on to fonn spennatocytes (Fig.

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