Models of viral hepatitis by Fritz von Weizsäcker, Michael Roggendorf

By Fritz von Weizsäcker, Michael Roggendorf

Viral hepatitis B or C is the commonest reason behind continual liver ailment all over the world and money owed for approximately eighty% of all hepatocellular carcinoma instances. therefore, battling viral hepatitis is still essentially the most urgent public well-being concerns at the present time. Animal types and cell-based structures are crucial instruments for addressing the numerous nonetheless unresolved simple and scientific difficulties. Experimental types are had to greater comprehend the viral existence cycles, pathogenetic facets and ordinary security mechanisms, whereas preclinical types are required for comparing novel preemptive and healing concepts. This monograph presents a different synopsis of at the moment to be had types of viral hepatitis, highlighting their specific use for uncomplicated and translational technology. prime specialists speak about new clinical effects and evolving tools in quite a few animal and in vitro types, together with the woodchuck, duck, mouse, chimpanzee and tupaia, in addition to fundamental hepatocytes and subgenomic HCV replicons.A important

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Bronte V, Apolloni E, Cabrelle A, et al: Identification of a CD11b(ϩ)/Gr-1(ϩ)/CD31(ϩ) myeloid progenitor capable of activating or suppressing CD8(ϩ) T cells. Blood 2000;96:3838–3846. Henderson RB, Hobbs JA, Mathies M, Hogg N: Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 2003;102:328–335. Mordue DG, Sibley LD: A novel population of Gr-1ϩ-activated macrophages induced during acute toxoplasmosis. J Leukoc Biol 2003;74:1015–1025. Sitia G, Isogawa M, Kakimi K, Wieland SF, Chisari FV, Guidotti LG: Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes.

The work was supported by the Deutsche Forschungsgemeinschaft, grant PR 618/2. References 1 2 WHO: Viral Hepatitis Prevention Board: Prevention and Control of Hepatitis B in the Community. WHO Communicable Series No 1 1996;1–26. Hoofnagle JH, di Bisceglie A: The treatment of chronic viral hepatitis. N Engl J Med 1997; 336:347–56. Transfer of HBV Genomes into Mice 39 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Zuckerman AJ, Lavanchy D: Treatment options for chronic hepatitis.

Graham FL, Smiley J, Russel WC, Nairn R: Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 1977;36:59–72. Oberwinkler/Untergasser/Sprinzl/Protzer 40 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 Petersen J, Dandri M, Gupta S, Rogler CE: Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma. Proc Natl Acad Sci USA 1998;95:310–315. Ohashi K, Marion PL, Nakai H, Meuse L, Cullen JM, Bordier BB, Schwall R, Greenberg HB, Glenn JS, Kay MA: Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses.

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