By S.R. Pandi-Perumal
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Additional resources for Melatonin: Biological basis of its function in health and disease
At a concentration (500 µM) that greatly exceeded that of melatonin, ascorbate was less effective in limiting the cardiac arrhythmias induced by I/R. 21 Also using the isolated rat heart model, the addition of melatonin to the reperfusion medium (after a 30 min ischemic episode) was found to decrease ventricular tachycardia and VF relative to their frequencies in the hearts that were only subjected to I/R. , left ventricular pressure, were also improved as a consequence of melatonin administration.
Gastroprotective effect of melatonin and its precursor, L-tryptophan, against stress-induced and ischemia-induced lesions is mediated by scavenging of oxygen free radicals. Scand J Gastroenterol 1997; 32:433-438. 56. Brzozowski T, Konturek PC, Konturek SJ et al. The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia and aspirin. J Pineal Res 1997; 23:79-89. 57. Cuzzocrea S, Costantino G, Mazzon E et al. Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion.
Oxidative damage to the liver induced by ischemia-reperfusion: Protection by melatonin. Hepatogastroenterology 1996; 43:898-905. 53. de la Lastra CA, Cabeza J, Motilva V et al. Melatonin protects against gastric ischemia-reperfusion in rats. J Pineal Res 1997; 23:47-52. Melatonin and Ischemia-Reperfusion Injury 25 54. Konturek PC, Konturek SJ, Majka J et al. Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects.