Listeria monocytogenes - A Medical Dictionary, Bibliography, by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference booklet. It provides an entire clinical dictionary masking countless numbers of phrases and expressions when it comes to Listeria monocytogenes. It additionally supplies broad lists of bibliographic citations. ultimately, it offers info to clients on the best way to replace their wisdom utilizing a variety of net assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with examine devoted to Listeria monocytogenes. in the event that your time is effective, this e-book is for you. First, you won't waste time looking the net whereas lacking loads of correct info. moment, the publication additionally saves you time indexing and defining entries. eventually, you won't waste time and cash printing enormous quantities of websites.

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Example text

Coli and V. cholerae-based vectors into nonprofessional antigen presenting cells and promoting their in situ lysis to deliver BD antigens or DNA vaccine constructs into these host cells. Replication-incompetent HSV vectors engineered to express BD antigens will be studied in various cell lines for kinetics and levels of BD antigen expression. All BD antigen-expressing vaccines will be evaluated for their ability to induce neutralizing antibodies as well as CD8 + T-cell responses in mice. The vectors will also be tested for their ability to protect animals against anthrax toxin and/or bacterial and viral challenge.

The LLO/PFO chimeras will be purified from E. coli and characterized biochemically. Next, the chimeras will be introduced into L. , In Aim II, the pathway of LLO processing in the host cytosol will be fully evaluated. LLO will be identified by metabolic labeling of L. monocytogenes within infected host cells, followed by immunoprecipitation. Precursor/product relationships will be determined by pulsechase experiments. Specific inhibitors will be used to evaluate the role of the proteosome and other proteases in degradation.

Aim 2 will functionally characterize L. monocytogenes mutants that are attenuated for virulence in flies. Bacterial gene products required for insect infection will be analyzed for potential roles in mammalian infection. Aim 3 will isolate and identify Drosophila mutants with altered susceptibility to Listeria infection. These studies will help identify the host factors that contribute to immune responses directed against intracellular pathogens. The ultimate goal of the experiments described will be the functional characterization of bacterial factors that support survival within the host, and the elucidation of host mechanisms that serve to counter bacterial survival strategies.

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