Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis by Ann Arvin, Gabriella Campadelli-Fiume, Edward Mocarski,

By Ann Arvin, Gabriella Campadelli-Fiume, Edward Mocarski, Patrick S. Moore, Bernard Roizman, Richard Whitley, Koichi Yamanishi

This definitive and accomplished account of the human herpes viruses offers an encyclopedic review in their uncomplicated virology and medical manifestations. This crew of viruses comprises human simplex style 1 and a couple of, Epstein Barr virus, cytomegalovirus and varicella-zoster virus. The illnesses they reason are major and infrequently recurrent. Their incidence within the constructed international money owed for an immense burden of illness, and consequently there's a good deal of analysis into the pathophysiology if an infection and immunobiology. one other very important region lined inside this quantity issues antiviral remedy and the improvement of vaccines. most of these points are lined intensive and the quantity is totally brand new either scientifically and when it comes to scientific directions for sufferer care. The textual content is generously illustrated all through and entirely referenced to the most recent study and advancements.

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Additional info for Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

Example text

Molecular phylogeny of the Alphaherpesvirinae subfamily and a proposed evolutionary timescale. J. Mol. , 238, 9–22. McGeoch, D. J. and Davison, A. J. (1999). The molecular evolutionary history of the herpesviruses. In Origin and Evolution of Viruses, ed. E. Domingo, R. Webster, and J. Holland, pp. 441– 465. London: Academic Press. McGeoch, D. J. and Gatherer, D. (2005). Integrating reptilian herpesviruses into the family Herpesviridae. J. , 79, 725–731. McGeoch, D. , Dalrymple, M. , Davison, A.

2004). , 2005). Given that gene duplication has been widely employed in host evolution (Prince and Pickett, 2002), and the greater evolutionary rates of herpesviruses, it seems likely that this means for generating diversity has played a greater part in herpesvirus evolution than can be detected by primary sequence comparisons. The Alphaherpesvirinae subfamily The employment of gene capture and duplication among the Beta- or Gammaherpesvirinae to generate diversity has received extensive attention in the literature (for details, see Chapters 15 and 22).

The case of HCMV provides a contemporary example. In the first analysis of the gene content of HCMV strain AD169, Chee et al. (1990) catalogued 189 protein-coding ORFs (counting duplicates once only). , 2003a,b). , 2004). Although the conservative numbers in this example are more supportable, the existence of unrecognized genes should not be ruled out even in well-characterized genomes, and candidates should be examined rigorously. , 1999). The genes of HSV-1, presumably like those of all herpesviruses, are transcribed by host RNA polymerase II Comparative analysis of the genomes (Wagner, 1985; Roizman and Knipe, 2001).

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