Enzyme-mediated resistance to antibiotics : mechanisms, by Robert A. Bonomo, Marcelo E. Tolmasky

By Robert A. Bonomo, Marcelo E. Tolmasky

Antibiotic-resistant micro organism, or "superbugs," current an more and more lethal chance to human overall healthiness. With chapters from the world's best researchers and students during this box, this entire quantity is a crucial and well timed evaluate of this serious subject.

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This publication provides a state of the art evaluate of the mechanisms of resistance. The enzymes and enzyme platforms particular during this paintings contain these excited by genetic reorganization, antibiotic Read more...

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Additional resources for Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition

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2. 19 Aminoglycoside Antibiotics 34. Li, X. , L. Zhang, G. A. McKay, and K. Poole. 2003. Role of the acetyltransferase AAC(6p)-Iz modifying enzyme in aminoglycoside resistance in Stenotrophomonas maltophilia. J. Antimicrob. Chemother. 51:803–811. 35. , M. Tod, Y. Cohen, and O. Petitjean. 1995. Aminoglycosides. Med. Clin. N. Am. 79:761–87. 36. , T. A. Smith, R. J. Zheng, P. Nordmann, and J. S. Blanchard. 2003. Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.

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Agents Chemother. 10:139–145. Kirst, H. , G. G. Marconi, F. T. Counter, P. W. Ensminger, N. D. Jones, M. O. Chaney, J. E. Toth, and N. E. Allen. 1982. Synthesis and characterization of a novel inhibitor of an aminoglycoside-inactivating enzyme. J. Antibiot. 12: 1651–1657. , M. Alam, Y. Nishimoto, S. Urasawa, N. Uehara, and N. Watanabe. 2001. Distribution of aminoglycoside resistance genes in recent clinical isolates of Enterococcus faecalis, Enterococcus faecium and Enterococcus avium. Epidemiol.

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