Endocrinopathy After Childhood Cancer Treatment (Endocrine by W.H.B. Wallace, C.J.H. Kelnar, P.-E. Mullis

By W.H.B. Wallace, C.J.H. Kelnar, P.-E. Mullis

Carrying on with advances within the administration of formative years malignancies bring about a swiftly becoming variety of early life melanoma survivors. even if, a lot of them adventure treatment-induced ‘late results’ together with an important variety of endocrine dysfunctions. during this e-book specialists within the box of past due results of youth melanoma therapy supply scientific perception into pertinent matters similar to the effect of melanoma cures on progress, puberty and hypothalamic and pituitary functionality, female and male fertility, weight problems, and metabolic and bone difficulties. Multidisciplinary long term follow-up of those sufferers is key to watch, deal with and forestall morbidity. accordingly this quantity is of serious curiosity to pediatric endocrinologists and oncologists, grownup and reproductive endocrinologists, fundamental care practitioners, nurses and nurse practitioners in addition to others interested in making plans and offering the holistic care which this more and more quite a few and critical workforce of sufferers calls for.

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Horm Res 1999;52:73–79. 91 Darzy KH, Shalet SM: Absence of adrenocorticotropin (ACTH) neurosecretory dysfunction but increased cortisol concentrations and production rates in ACTH-replete adult cancer survivors after cranial irradiation for nonpituitary brain tumors. J Clin Endocrinol Metab 2005;90:5217– 5225. 92 Mohn A, Chiarelli F, Di Marzio A, Impicciatore P, Marsico S, Angrilli F: Thyroid function in children treated for acute lymphoblastic leukemia. J Endocrinol Invest 1997;20:215–219. 93 Lando A, Holm K, Nysom K, Rasmussen AK, Feldt-Rasmussen U, Petersen JH, Muller J: Thyroid function in survivors of childhood acute lymphoblastic leukaemia: the significance of prophylactic cranial irradiation.

Note the impact of spinal irradiation and that of GH deficiency (GHD) or GH insufficiency (GHI) on the basal and stimulated TSH levels. N = Normals; P1 = CIR patients without GHD; P2 = CSI patients without GHD; P3 = CSI patients with GHI; P4 = CSI patients with GHD. Reproduced with permission from Darzy and Shalet [97]. Abnormalities of Prolactin Secretion Radiation-induced hyperprolactinaemia, due to a reduction in the inhibitory neurotransmitter dopamine, has been described in both sexes and all age groups but is most frequently encountered in the adult female with radiation doses of >40 Gy.

N Engl J Med 1981;304: 1121–1124.

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