By David J. Torpy MBBS, PhD, George P. Chrousos MD, DSs (auth.), K. Patrick Ober MD (eds.)
Endocrinology of severe disorder bargains the practising health care professional who cares for the acutely in poor health a travel de strength survey of the responses of the endocrine process to severe disease, illuminating alongside the best way the mechanisms at play and the results (both optimistic and negative). The state of the art contributions accumulated the following hide the endocrine reaction to a mess of significant health problems, together with melanoma, liver failure, renal failure, trauma, burns, AIDS and different infections, hunger, cardiac ailment, pulmonary affliction, and organ transplants. in addition they clarify tips on how to distinguish worthy endocrine responses from deleterious responses which may have a long term destructive influence on scientific outcomes.
Endocrinology of serious ailment opens the door to a greater realizing of the various scientific issues which can set off an endocrine reaction, the scope of those responses, and the influence of the endocrine reaction at the underlying disorder strategy. The e-book turns into a necessary reference for state-of-the-art serious care physicians, in addition to all those that needs to deal with more and more complicated scientific issues and care for the serious health problems of sufferers below extensive care.
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Additional resources for Endocrinology of Critical Disease
AI-Damluji S, Rees LH. The neuroendocrine control of corticotropin secretion in normal humans and in Cushing's disease. In: Collu R, Brown GM, Van Loon GR, eds. Clinical Neuroendocrinology. 251-286. 96. Liposits Z, Phelix C, Paull WK. Electron microscopic analysis of tyrosine hydroxylase, dopamine~-hydroxylase and phenylethanolamine-N-methyitransferase immunoreactive innervation of the hypothalamic paraventricular nucleus in the rat. Histochemistry 1986;84: 105-120. 97. Cummings S, Elde R, Ells J, Lindall A.
Crofford LJ, Sano H, Karalis K, Friedman TC, Epps HR, Remmers EF, Mathern P, Chrousos GP. Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. J ImrnunoI1993;151:1587-1596. 127. Sternberg EM, Glowa JR, Smith MA, Calogero AE, Listwak SJ, Aksentijevich S, Wilder RL, Chrousos GP. Corticotropin releasing hormone related behavioral and neuroendocrine responses to stress in Lewis and Fisher rats. Brain Res 1992;570:54-60. 128. Vamvakopoulos NC, Chrousos GP.
It appears that the fetus responds in a similar fashion to intrauterine stress, particularly with regard to reduced OS formation, which leads to reductions in placental estrogen synthesis. For example, reduced levels of maternal estrogen levels and low estrogen concentrations in amniotic fluid have been reported in association with many pregnancy complications (86). Subnormal levels of OS have been noted at delivery in newborns of women having complications such as pregnancyinduced hypertension (87,88), fetal growth retardation (89,90), and hypoxemia (91).