By Hosam K. Kamel MD, Arshag D. Mooradian MD, Tanveer Mir MD (auth.), John E. Morley MB, BCh, Lucretia van den Berg MB, BCh (eds.)
In Endocrinology of getting older, a panel of extraordinary physicians significantly reports the scientific outcomes of the endocrinological alterations that take place with aging-in either males and women-and learn using hormonal remedy to minimize them. themes diversity from bone affliction and water stability in all older humans, to androgen deficiency in getting older men, gynecomastia, and menopause. The authors additionally speak about style II diabetes in folks over sixty five, emphasizing the cognitive merits of fine glycemia regulate, and the interplay of foodstuff and metabolism, targeting hypocholesterolemia, weight problems, the anorexia of getting older, hint parts, and supplements. The getting older of the sympathetic apprehensive method and its influence on high blood pressure within the aged is additionally lined. well timed and authoritative, Endocrinology of getting older bargains endocrinologists, geriatricians, and first care physicians severe perception into the endocrine difficulties of our speedily growing to be aged inhabitants. the dear info right here will vastly increase each physician's skill to augment functionality of their getting older sufferers via insightful program of contemporary remedy regimes and modern robust new therapeutics.
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Additional info for Endocrinology of Aging
In addition, fat is redistributed from peripheral to central sites and total body water decreases. The same qualitative body composition changes are present in younger adults who are GH-deficient as a result of pituitary or hypothalamic disease, and these changes can be at least partially reversed by GH treatment (38,82). Similarly, GH treatment of young adults with organic GH deficiency increases bone density (83), and bone density is proportional to circulating IGF-I concentrations in elderly women (84), suggesting that GH-IGF-I deficiency may contribute to the decline in bone density and increased incidence of osteoporosis that accompanies normal aging.
Intracellular calcium concentration and growth hormone secretion in individual somatotropes: effects of growth hormone-releasing factor and somatostatin. Endocrinology 1988; 122:2927-2932. 13. Holl RW, Thorner MO, Mandell GL, Sullivan JA, Sinha YN, Leong DA. Spontaneous oscillations of intracellular calcium and growth hormone secretion. J BioI Chern 1988;263:9682-9685. 14. Herman V, Weiss M, Becker D, Melmed S. Hypothalamic hormonal regulation of human growth hormone gene expression in somatotroph adenoma cell cultures.
Chapman 28 Effects of Age-Related Decline in GH-IGF-I Axis Aging is associated with significant changes in body composition. Between the ages of 30 and 75 yr, the mean percentage body fat increases by up to 100%, muscle mass decreases by 20-50%, and bone mass by 20% (81). The decrease in muscle mass is associated with a reduction in muscle strength. In addition, fat is redistributed from peripheral to central sites and total body water decreases. The same qualitative body composition changes are present in younger adults who are GH-deficient as a result of pituitary or hypothalamic disease, and these changes can be at least partially reversed by GH treatment (38,82).