Dengue by Scott B. Halstead

By Scott B. Halstead

This distinctive quantity provides an updated evaluate of 1 of the realm s significant illnesses -- ailments as a result of the 4 dengue viruses. It starts with an insightful tale of the foundation of dengue sickness outbreaks, together with the emergence of serious and deadly dengue hemorrhagic fever. The nature, constitution and biology of the 4 dengue viruses are defined, and a significant section of the e-book is targeted at the epidemiology of dengue as a mosquito-borne affliction. this can be complemented by means of opinions of present mosquito regulate courses through 3 teams of exceptional professionals. The most powerful section of the quantity is its complete description of the present figuring out of dengue sickness pathogenesis, via an research of the professionals and cons of 5 of the main arguable components within the box: the WHO DEF case definition, secondary dengue infections, virulent viruses, the function of irregular T cells and autoimmunity.

Contents: Dengue: assessment and background (S B Halstead); The Infectious Agent (D W C Beasley & A D T Barrett); Epidemiology (S B Halstead); Resistance to an infection (D W Vaughn et al.); medical positive factors of Dengue (J Farrar); administration of Dengue (B Wills); Pathogenesis: probability components sooner than an infection (S B Halstead); removing of an infection (A L Rothman & F A Ennis); Pathophysiology (S B Halstead); analysis of Dengue Virus Infections (T P Endy et al.); The keep an eye on of Dengue Vectors (N G Gratz & S B Halstead); organic keep watch over of Dengue Vectors: delivers from the earlier (B H Kay); Mosquito keep an eye on: Behavioral and neighborhood Interventions (P Winch et al.); Controversies (J Rigau-Perez et al.).

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56,57 Other viruses Using historical accounts, the etiology of febrile exanthems can easily be confused. The most dramatic mix-up seems to have been caused by a virus known now as chikungunya, an alphavirus in the Togaviridae genus. 58 An account cited for many years as the initial description of dengue fever was, in fact, probably on chikungunya. David Bylon,59,60 “stads cirurgyn” of Batavia (Jakarta), described an epidemic of a febrile disease with an acute onset and joint involvement in 1779.

101. 102. 103. 104. 105. 106. 107. 108. 109. 110. Fischer DB, Halstead SB. Observations related to pathogenesis of dengue hemorrhagic fever. V. Examination of age-specific sequential infection rates using a mathematical model. Yale J Biol Med 1970;42:329–349. Winter PE et al. An insular outbreak of dengue hemorrhagic fever. I. Epidemiologic observations. Am J Trop Med Hyg 1968;7:590–599. Russell PK et al. An insular outbreak of dengue hemorrhagic fever. II. Virologic and serologic studies. Am J Trop Med Hyg 1968;17:600–608.

Kao Hsuing I Hsueh Ko Hsueh Tsa Chi 1989;5:1–11 (in Chinese). Rigau-Perez J et al. Dengue and dengue haemorrhagic fever. Lancet 1998a;352:971–977. Saluzzo JF. Isolation of dengue 2 and dengue 4 viruses from patients in Senegal. Trans R Soc Trop Med Hyg 1986;80:5. Halstead SB et al. Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg 2001;65:180–183. qxd 9/16/2008 12:26 PM Page 23 Dengue: Overview and History 23 36. 37. 38. 39. 40. 41. 42.

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