Cytotoxic T-Lymphocytes in Human Viral and Malaria by M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

By M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

Cytotoxic T lymphocytes (CTL) keep an eye on a number of viral infections in animals in accordance with deletion and reconstitution experiments with CTL clones and use of CD8 genetically poor (knock-out) mice. during this quantity, info for the function that CTL play in human infectious ailments is gifted. As such, this represents the 1st quantity within which such details from a number of diversified viral and protozoan infections is introduced together.

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Polyclonal CD8+ CMVspecific CTL were generated by stimulating PBL obtained from the bone marrow donor with autologous CMV-infected fibrolasts, and T cell clones were isolated from the polyclonal CTL cultures by limiting dilution cloning. Screening assays were used to identify CD3+ CD8+ CD4 - T cell clones which lysed autologous CMV - infected fibroblasts in a class I M H C-restricted manner, but failed to lyse uninfected fibroblasts. Clones were also assayed for lysis of fibroblasts and EBV -transformed B cells derived from the BMT recipient to identify and exclude from use in therapy any CTL with crossreactivity for recipient minor histocompatibility antigens.

1988) and in the SIV-infected rhesus macaque model (TSUBOTA et al. 1989; MILLER et al. 1990,1991; SHEN et al. 1991; BOURGAULT et al. 1992; VENET et al. 1992), providing additional sources of retrovirus-specific CTL. 2 Sources of Target Cells Cytotoxic T cells recognize processed viral peptides presented in association with MHC molecules (TOWNSEND et al. 1986; TOWNSEND and BODMER 1989; YEWDELL and BENNINK 1992). For CD8+ CTL, these antigens consist of peptides eight to 11 amino acids in length that are presented in the cleft of a class I MHC molecule (ROTZSCHKE et al.

Virus Type . . . . . 1 . . . . . . . . . . . Replication . . . . . . . by . 1 Introduction Following the identification of the human immunodeficiency virus type 1 (HIV-1) as the etiologic agent of acquired immunodeficiency syndrome (AI DS; BARRE-SINOUSSI et al. 1983; GALLO et al. 1984), an intensive effort has been undertaken to characterize humoral and cellular immune responses to this retrovirus. Although the immunologic correlates of protective immunity are yet to be precisely identified, accumulating evidence suggests that cytotoxic T lymphocytes (CTL) may playa central role in containing viral replication during the typically prolonged asymptomatic phase of this illness.

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