By James J. Butler (auth.), John M. Bennett M.D. (eds.)
Where do you start to appear for a contemporary, authoritative article at the analysis or administration of a specific malignancy? The few basic oncology textbooks are often old-fashioned. unmarried papers in really good journals are informative yet seldom finished; those are extra frequently initial studies on a really restricted variety of sufferers. definite basic journals usually submit sturdy in intensity stories of melanoma themes, and released symposium lectures are frequently the simplest overviews to be had. regrettably, those reports and supplementations look sporadically, and the reader can by no means confirm whilst a subject of distinctive curiosity should be lined. melanoma therapy and study is a chain of authoritative volumes which target to fulfill this desire. it truly is an try to determine a serious mass of oncology literature protecting almost all oncology issues, revised usually to maintain the insurance brand new, simply to be had on a unmarried library shelf or by means of a unmarried own subscription. we've got approached the matter within the following model. First, through dividing the oncology literature into particular subdivisions similar to lung melanoma, geni tourinary melanoma, pediatric oncology, and so on. moment, by way of asking eminent gurus in each one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. every one subject and tumor sort is roofed in a quantity showing usually and predictably, discussing present prognosis, staging, markers, all kinds of therapy modalities, simple biology, and more.
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The place do you start to seem for a up to date, authoritative article at the prognosis or administration of a specific malignancy? The few common oncology textbooks are as a rule outdated. unmarried papers in really good journals are informative yet seldom finished; those are extra frequently initial stories on a really restricted variety of sufferers.
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Additional info for Controversies in the Management of Lymphomas: Including Hodgkin’s disease
Kadin ME, Glatstein E, Dorfman RF: Clinicopathologic studies of 117 untreated patients subjected to laparotomy for the staging of Hodgkin's disease. Cancer 27:1277-1294, 1971. 52. Strum SB, Rappaport H: Interrelations of the histologic types of Hodgkin's disease. Arch Pathol 91:127-134, 1971. 53. Colby TV, Warnke RA: The histology of the initial relapse of Hodgkin's disease. Cancer 45:289-292, 1980. 54. Seenmayer TA, Lagace R, Schurch W: On the pathogenesis of sclerosis and nodularity in nodular sclerosing Hodgkin's disease.
Spleen Careful gross examination of the spleen is as important as the microscopic evaluation. The entire spleen should be sliced fresh at 2-3 mm intervals and all cut surfaces examined. The gross findings in the spleen are prognostically important: the presence of five or more grossly identified nodules, regardless of size, conveys a worse prognosis . Suspicious foci and any obvious tumor nodules should be taken for microscopic evaluation. Four blocks are usually adequate, and overnight fixation gives best results.
Although by combining the architectural features seen in the frozen section with cytologic features assessed in a good touch preparation from the freshly cut node surface, one can often make a definitive diagnosis. Relatively few individuals attain enough experience with touch preparations of HD to be proficient. If touch preparations are fixed immediately in alcohol and stained with hematoxylin and eosin the cytologic features closely approximate those seen in paraffin sections. From a practical point of view frozen sections should be used to assure that adequate tissue is present for the diagnosis on permanent section.