Concepts in Viral Pathogenesis III by Stephen C. Harrison (auth.), Abner Louis Notkins M.D.,

By Stephen C. Harrison (auth.), Abner Louis Notkins M.D., Michael B. A. Oldstone M.D. (eds.)

The all new techniques in Viral Pathogenesis III includes the commonly praised structure of offering updated info in pithy, simply learn "mini-review" kind and enhances past variations with contributions by means of major overseas gurus on structure-function relationships, gene rules, phone biology of viral infections, transgenic mice, expression of viral genes, retroviruses, and evolving ideas in viral illnesses. Taken jointly, quantity I, II and III of Concepts in Viral Pathogenesis include a hundred forty five designated chapters each one representing the most recent pondering in vital parts of virology by way of the most important investigators within the box. Clinicians, laboratory scientists, scholars, and others looking authoritative overviews of present wisdom at the mechanism of viral illnesses will welcome this priceless resource.

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At least for the type 3 vaccine, virus replication in the gut may also be reduced by the attentuating mutation in VP3, which is present in intestinal virus for several weeks after vaccination [15], Although the VP3-attenuating mutation subsequently reverts, resulting in excreted viruses that are nearly as neurovirulent as the parent of the vaccine (P. Minor, personal communication), spread to the CNS may be precluded at that time by a vigorous antibody response. Alternatively, the vaccine strains might contain mutations that specifically attenuate oral neurovirulence, which have not been detected in the studies summarized above that assay for monkey spinal neurovirulence.

Virology 47:753-760 34. Kamer G, Argos P (1984) Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses. Nucleic Acids Res 12: 7269-7282 35. Ahlquist P, Strauss EG, Rice CM, Strauss JH, Haseloff J, Zimmern D (1985) Sindbis virus proteins nsPI and nsP2 contain homology to non structural proteins from several RNA plant viruses. J Virol 53:536-542 36. Marsh M, Helenius A (1988) Virus entry into animal cells. Adv Virus Research (in press) 37. FitzGerald DLP, Padmanabhan R, Pastan I, Willingham M (1983) Adenovirusinduced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis.

18. 19. 20. 21. 22. 23. of poliovirus type 2 Lansing antigenic variants selected with monoclonal antibodies. Virology 161:429-437 Evans DMA, DunnG, MinorPD, Schild GC, CannAJ, Stanway G, AlmondJW, Currey K, Maizel JV (1985) Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature 314:548-550 Sabin AB (1956) Present status of attenuated live-virus poliomyelitis vaccine. J Amer Med Assoc 162:1589-1596 Bodian D, Horstmann DH (1965) Polioviruses.

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