Apoptosis, Cell Signaling, and Human Diseases: Molecular by Rakesh Srivastava

By Rakesh Srivastava

Apoptosis, telephone Signaling, and Human ailments: Molecular Mechanisms, Volumes 1 and a pair of, current a concise synthesis of modern advancements within the figuring out of either phone survival and apoptotic pathways. specific awareness is given to apoptosis in human illnesses, comparable to various types of melanoma. those accomplished volumes combine the main cutting edge and present findings. The members are on the vanguard of medical discovery.

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Mol Endocrinol 1994;8:5–11. 33. Meinkoth JL, Ji Y, Taylor SS, Feramisco JR. Dynamics of the distribution of cyclic AMPdependent protein kinase in living cells. Proc Natl Acad Sci USA 1990;87:9595–9599. 34. Vallee RB, DiBartolomeis MJ, Theurkauf WE. A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2). J Cell Biol 1981;90(3):568–576. 35. Imaizumi-Scherrer T, Faust DM, Barradeau S, Hellio R, Weiss MC. Type I protein kinase a is localized to interphase microtubules and strongly associated with the mitotic spindle.

Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem 1986;261:15,360–15,363. 19. Showers MO, Maurer RA. A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem 1986;261:16,288–16,291. 20. Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T. Molecular cloning of a unique tissue-specific protein kinase (C-gamma) from human testis—representing a third isoform for the catalytic subunit of the cAMP-dependent protein kinase.

Overexpression of RIα-P, which functionally mimics RIIβ, downregulated ECPKA expression as compared with that by RIα, and mutant RIIβ-P, a functional mimic of RIα, upregulated ECPKA as compared with RIIβ cells. Overexpression of mutant Cα, which lacks the N-terminal myristate, upregulated total cellular PKA activity and PKA-I holoenzyme, but barely increased ECPKA, indicating a structural requirement of ECPKA secretion (166). Increase of functional PKA-I via RIα or Cα overexpression in the cell, which may promote cell proliferation and neoplastic transformation, enhances ECPKA secretion; conversely, ECPKA secretion is decreased in tumor cells that are growth arrested via RIIβ overexpression, which downregulates PKA-I and upregulates PKA-IIβ (RIIβ containing PKA-II).

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