Advances in Molecular and Cellular Endocrinology, Vol. 2 by Derek LeRoith

By Derek LeRoith

Quantity 2 has considering elements of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. moreover, thyroid melanoma and steroidogenic enzymes and precocious puberty are coated. ultimately, the "hot issues" comprise leptin and development issue signaling.

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1994). Because the WSXWS extracellular motif is conserved in the class I cytokine receptor superfamily, this region has been postulated to play a role in both ligand binding and signal transduction. , 1994). Separate mutations at y222 and S =6 diminished ligand binding and abolished signal transduction, as measured both by stimulation of protein synthesis and by transcriptional activation of a transiently transfected c-fos promoter reporter gene. Mutations at G 223, E TM, and F 22s did not alter receptor function.

269, 7874-7878. , & Schindler, C. (1996). The SH2 domains of STAT1 and STAT2 mediate multiple interactions in the transduction of INF-t~ signals. EMBO J. 15, 1075-1084. C. (1995). Mapping of the cytoplasmic domain of the human growth hormone receptor required for the activation of JAK2 and STAT proteins. J. Biol. Chem. 270, 21326-21330. , & Horn, F. (1996). Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130.

15, 2425-2433. , & Kishimoto, T. (1991). Critical cytoplasmic region of the IL-6 signal transducer, gp 130, is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. USA 88, 11349-11353. A. (1995). Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract. Am. J. Physiol. 268, G431-G442. Y. (1994). Differential signal transduction of the short, Nb2 and long prolactin receptors. J. Biol. Chem. 269, 26076-26082. T. (1996). Multiple cis-trans conformers of the prolactin receptor proline-rich motif(PRM) peptide detected by reverse-phase HPLC, CD, and NMR.

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