By Philip W. Harvey, David J. Everett, Christopher J. Springall
Despite being considered as the commonest toxicological goal within the endocrine process, the adrenal gland has usually been missed in regulatory checking out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes suggestions on hand to check adrenal endocrine disruption.
Examining present strategies and the most recent developments, Adrenal Toxicology stories the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents info at the variety of substances and chemical substances that impact adrenocortical functionality and indicates standardized methods for in vivo and in vitro overview. This quantity additionally provides contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.
Adrenal Toxicology :
- reflects the most important advancements revamped the previous decade
- focuses at the newest examine concepts, together with their makes use of and limitations
- provides an built-in method for adrenal toxicology evaluation
- identifies wisdom and knowledge gaps, supplying impetus for regulatory consideration
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Extra resources for Adrenal Toxicology
Molecular and systems pharmacology of glucocorticosteroids. In: Harvey PW, ed. The Adrenal in Toxicology: Target Organ and Modulator of Toxicity. London: Taylor & Francis, 1996:81–128. Guzman J, Ruiz J, Eshraghi AA, et al. Triamcinolone acetonide protects auditory hair cells from 4-hydroxy-2,3-nonenal (HNE) ototoxicity in vitro. Acta Otolaryngol 2006; 126:685–690. Hadley AJ, Flack JD, Buckingham JC. Modulation of corticotrophin release in vitro by methylxanthines and adenosine analogues. Br J Pharmacol 1990; 100(suppl): 337.
In: Harvey PW, Rush KC, Cockburn A, eds. Endocrine and Hormonal Toxicology. Chichester: John Wiley, 1999: 3–11. Harvey PW, Er J, Fernandes C, et al. Corticosterone does not cause testicular toxicopathology in the rat: Relevance to methylxanthines, ACTH and stress. Hum Exp Toxicol 1992; 11:505–509. Harvey PW, Healing G, Rees SJ, et al. Glucocorticosteroid interactions with natural toxins: A mini review. Nat Toxins 1994; 2:341–346. Harvey PW, Healing G, Major IR, et al. Glucocorticoid amelioration of nephrotoxicity: A study of cephaloridine-methylprednisolone interaction in the rat.
The Adrenal Gland. 2 nd ed. New York, NY: Academic Press, 1992:131–158. Camacho AM, Cash R, Brough AJ, et al. Inhibition of adrenal steroidogenesis by aminoglutethimide and the mechanism of action. J Am Chem Soc 1967; 202:114–120. Canton RF, Sanderson JT, Nijmeijer S, et al. In vitro effects of brominated flame retardents and metabolites on CYP17 catalytic activity: A novel mechanism of action. Toxicol Appl Pharmacol 2006; 216:274–281. Champoux L, Rodrigue J, Trudeau S, et al. Contamination and biomarkers in the great blue heron, an indicator of the state of the St.