Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel

By David T. Curiel

Adenoviral Vectors for Gene remedy, moment Edition presents distinct, complete assurance of the gene supply autos which are in response to the adenovirus that's rising as a major device in gene treatment. those fascinating new healing brokers have nice strength for the remedy of sickness, making gene treatment a fast-growing box for learn.

This booklet provides subject matters starting from the fundamental biology of adenoviruses, throughout the development and purification of adenoviral vectors, state-of-the-art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory matters surrounding human medical gene remedy trials. This extensive scope of knowledge presents a pretty good assessment of the sector, permitting the reader to realize a whole realizing of the advance and use of adenoviral vectors.

  • Provides entire insurance of the elemental biology of adenoviruses, in addition to their development, propagation, and purification of adenoviral vectors
  • Introduces universal concepts for the improvement of adenoviral vectors, in addition to state of the art tools for his or her improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses application of adenoviral vectors in animal ailment models
  • Considers Federal Drug management laws for human scientific trials

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Additional info for Adenoviral Vectors for Gene Therapy, Second Edition

Example text

Persson BD, Schmitz NB, Santiago C, Zocher G, Larvie M, Scheu U, et al. Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. PLoS Pathog 2010;6:e1001122. Greber UF, Willetts M, Webster P, Helenius A. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 1993;75:477–86. Wiethoff CM, Wodrich H, Gerace L, Nemerow GR. Adenovirus protein VI mediates membrane disruption following capsid disassembly. J Virol 2005;79:1992–2000.

1 Protein VI for Membrane Lysis Endosomal escape is efficient, with a success rate of 80–95% for HAdV-C581,173,205 and occurs rapidly. 173 Endosomal penetration of HAdV is coupled to the stepwise nature of uncoating, as indicated by studies of HAdV-C2/5 and the mutant TS1. The TS1 mutant is not infectious. 206 Underlying reasons are an uncoating defect of TS1, which precludes exposure of the membrane lytic factor VI. This defect occurs because TS1 fails to respond to mechanical cues from receptors on the plasma membrane.

Role of the I7 protein in proteolytic processing of vaccinia virus membrane and core components. J Virol 2004;78:6335–43. Andres G, Alejo A, Simon-Mateo C, Salas ML. African swine fever virus protease, a new viral member of the SUMO-1-specific protease family. J Biol Chem 2001;276:780–7. Stephens RS, Kalman S, Lammel C, Fan J, Marathe R, Aravind L, et al. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 1998;282:754–9. Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB, et al.

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