2014 Nelson's Pediatric Antimicrobial Therapy by John S. Bradley MD, John D. Nelson MD Emeritus, Dr.

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

New twentieth Edition!  This bestselling and known source on pediatric antimicrobial remedy offers speedy entry to trustworthy, up to the moment thoughts for therapy of all infectious ailments in little ones.  

For each one illness, the authors offer a statement to aid future health care services choose the easiest of all antimicrobial choices.  Drug descriptions conceal all antimicrobial brokers to be had this present day and comprise entire information regarding dosing regimens. based on becoming matters approximately overuse of antibiotics, this system contains instructions on whilst to not prescribe antimicrobials.

Practical, evidence-based innovations from the specialists in antimicrobial treatment:

  • Developed through exclusive editorial board

  • Designed when you look after youngsters and are confronted with judgements each day

  • Includes therapy of parasitic infections and tropical medicine.

  • Updated checks in regards to the power of the advice and the point of proof for remedy techniques for significant infections

  • Anti-infective drug directory, entire with formulations and dosages

  • Antibiotic treatment for overweight children

  • Antimicrobial prophylaxis/prevention of symptomatic infection

  • Maximal grownup dosages and better dosages of a few antimicrobials conventional in children

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Extra resources for 2014 Nelson's Pediatric Antimicrobial Therapy

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5 mg/kg q24h (see Chapter 11). b Desired serum concentrations: 20–30 mg/L (peak), <5 mg/L (trough). c Desired serum concentrations: 5–10 mg/L (peak), <2 mg/L (trough). a C. AMINOGLYCOSIDES Empiric Dosage (mg/kg/dose) by Gestational and Postnatal Age 2014 Nelson’s Pediatric Antimicrobial Therapy — 35 5 3/13/14 2:54 PM 36 — Chapter 5. Antimicrobial Therapy for Newborns E. Use of Antimicrobials During Pregnancy or Breastfeeding Antimicrobial Therapy for Newborns The use of antimicrobials during pregnancy should be balanced by the risk of fetal toxicity, including anatomical anomalies.

Indb 25 MSSA: oxacillin/nafcillin IV for 21 days minimum (AIII) MRSA: vancomycin IV OR clindamycin IV if susceptible (AIII) for 21 days minimum Penicillin G IV OR ampicillin IV, IM for 10 days (AIII) Azithromycin PO/IV for 5 days or clarithromycin PO for 10 days (BIII) –– S aureus17,75–77 –– Group B streptococcus78,79 –– Ureaplasma spp (urealyticum or parvum)80 Antimicrobial Therapy for Newborns Pathogenic role of Ureaplasma not well defined and no prophylaxis recommended for CLD Many Ureaplasma spp resistant to erythromycin Association of erythromycin and pyloric stenosis in young infants For serious infections, ADD gentamicin for synergy until clinically improved.

Newborns Cefixime 8 mg/kg/day PO as a single daily dose has not yet been studied in children but is recommended as step-down therapy in adults, to complete a 7-day treatment course. 40 For MSSA: cephalexin OR cloxacillin caps for older children. For Kingella, most penicillins or cephalosporins (but not clindamycin). 41 Arthritis, bacterial36–40 NOTE: CA-MRSA (see Chapter 4 on CA-MRSA) is increasingly prevalent in most areas of the world. Recommendations below are given for CA-MRSA and MSSA. Antibiotic recommendations for empiric therapy should include CA-MRSA when it is suspected or documented, while treatment for MSSA with beta-lactam antibiotics (like cephalexin) is preferred over clindamycin.

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